Muscle Biophysics: From Molecules to Cells

Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. This book centers mostly on mechanical studies, dealing with force production and regulation; it gathers studies performed by scientists who have used diverse muscle techniques, and who have shaped the field of muscle contraction throughout the past years. Starting with theoretical approaches to understand myosin molecule function and energetics, this book covers experimental work performed with single molecules, and discusses results from studies investigating basic mechanisms of contraction, using (mostly in order of appearance) isolated sarcomeres, myofibrils, and fibers are presented. The last chapters summarize studies investigating the effects of acute and chronic adaptations, including weakness and muscle disease. Muscle Biophysics represents an excellent source of information for readers intending to understand the mechanics of muscle contraction, and is a fascinating collection of chapters that will hopefully stimulate young investigators to pursue research in this exciting field of research.